George Musser was born in 1806 in Montgomery, Virginia to Adam Musser and Maria (Cormany) Musser. On February 13, 1827 he was married to Elizabeth Crow in Wythe, Virginia. The couple continued to reside in Wythe/Smythe after their marriage. Here they had children David (1827), Anna Margaretta (June 20, 1829), Thomas (1831), Adam (1832), George (November 29, 1834), Sarah (1840), Mary Rachel (February 12, 1840), Ledy (1844), Joseph (1846), Franklin Jonas (1851), Martin (June 20, 1851), and Barbara (1852). George passed away in 1874.